The Higher Relative Doses of Acute Capsaicin Supplementation Enhance the Performance of Trained Men in Resistance Training
DOI:
https://doi.org/10.51224/SRXIV.558Keywords:
Supplements, Performance-Enhancing Substances, Strength Training, TRPV Cation ChannelsAbstract
Objectives: This study aims to compare the efficacy of acute capsaicin supplementation on strength tests and psychophysiological parameters using different doses, relative to total body mass. Methods: The sample consisted of 19 male volunteers with a mean age of 23.4±3.2 years. The volunteers consumed either a lower dose of capsaicin (0.15 mg/kg) (LCAP), a higher dose of capsaicin (0.35 mg/kg) (HCAP), or a placebo (PLA). After 45 minutes, the volunteers performed four sets of the back squat exercise. The first set was performed until concentric failure to determine the number of maximum repetitions (NRM). In the following three sets, a maximum of 12 repetitions was performed at an intensity of 70% of 1RM, with a two minute rest between sets. Total volume (TV), movement speed (MS), lactate concentration, and rating of perceived exertion (RPE) were evaluated. Results: The results showed a significant increase in TV with HCAP (p=0.019) compared to LCAP and PLA, while LCAP showed no significant difference compared to PLA (p=1.00). Additionally, there were no changes in MS (p=0.495), lactate concentration (p=0.733), or RPE (p=0.554), regardless of the capsaicin dose. Conclusion: Acute capsaicin supplementation can increase TV, but only at high doses, without causing significant changes in MS, lactate concentration, or RPE.
Metrics
References
Kerksick CM, Wilborn CD, Roberts MD, et al. ISSN exercise & sports nutrition review update: research & recommendations. J Int Soc Sports Nutr. 2018;15(1):38. doi:10.1186/s12970-018-0242-y.
Peeling P, Binnie MJ, Goods PSR, Sim M, Burke LM. Evidence-based supplements for the enhancement of athletic performance. Int J Sport Nutr Exerc Metab. 2018;28(2):178-187. doi:10.1123/ijsnem.2017-0343
Grgic J, Mikulic P, Schoenfeld BJ, et al. Effects of capsaicin and Capsiate on endurance performance: A meta-analysis. Nutrients. 2022;14(21):4531. doi:10.3390/nu14214531
Matta JA, Ahern GP. TRPV1 and synaptic transmission. Curr Pharm Biotechnol. 2011;12(1):95-101. doi:10.2174/138920111794295725
Hudson ASR, Hudson MC, Hudson MP, Oliveira AA, Costa NCS. Involvement of the TRPV1 channel in the modulation of spontaneous locomotor activity, physical performance, and physical exercise-induced physiological responses. Braz J Med Biol Res. 2016;49(6):e5235. doi:10.1590/1414-431x20165235
Lotteau S, Ducreux S, Romestaing C, et al. Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle. PLoS One. 2013;8(3):e58673. doi:10.1371/journal.pone.0058673
Vahidi Ferdowsi P, de Souza JM, Hargraves TL, et al. TRPV1 activation by capsaicin mediates glucose oxidation and ATP production independent of insulin signaling in mouse skeletal muscle cells. Cells. 2021;10(6):1560. doi:10.3390/cells10061560
Taylor JL, Amann M, Duchateau J, Meeusen R, Rice CL. Neural contributions to muscle fatigue: from the brain to the muscle and back again. Med Sci Sports Exerc. 2016;48(11):2294-2306. doi:10.1249/MSS.0000000000000923
Butenas AL, Saito A, Mizuno M, Ichinose M, Homma S. Sex-dependent attenuating effects of capsaicin administration on the mechanoreflex in healthy rats. Am J Physiol Heart Circ Physiol. 2023;325(2):H372-H384. doi:10.1152/ajpheart.00169.2023
Freitas MC, Azevedo LM, Moreira SB, et al. Acute capsaicin supplementation improvises resistance training performance in trained men. J Strength Cond Res. 2018;32(8):2227-2232. doi:10.1519/JSC.0000000000002381
Silva BVC, Sousa M, Franco-Alvarenga PE, et al. Acute supplementation with capsaicin enhances upper-limb performance in male Jiu-Jitsu athletes. Sports. 2022;10(8):120. doi:10.3390/sports10080120
Gomes WDS, Almeida JA, Souza DB, et al. Effects of Capsiate supplementation on maximal voluntary contraction in healthy men. Int J Sports Med. 2021;42(6):548-555. doi:10.1055/a-1335-7871
Grgic J, Mikulic P, Schoenfeld BJ, et al. Effects of capsaicin and Capsiate on endurance performance: A meta-analysis. Nutrients. 2022;14(21):4531. doi:10.3390/nu14214531
Simões CB, Moreira SB, Cavalcante T, et al. Acute caffeine and capsaicin supplementation and performance in resistance training. Motriz: J Phys Educ. 2022;28:e1022008. doi:10.1590/S1980-6574202200081022
Moura HPSN, Esteves GP, De Souza Neto AV, et al. Acute low-dose Capsiate supplementation improves upper body resistance exercise performance in trained men: A randomized, crossover and double-blind study. Int J Exerc Sci. 2022;15(2):1007-1018.
Cruz VM, Jiménez-Martínez P, Peinado AB, et al. Combined caffeine-capsaicin supplementation does not enhance the performance of trained men in a resistance session. Muscles Ligaments Tendons J. 2023;13(4):645-652. doi:10.32098/mltj.04.2023.12
Cross BL, Gallego J, Rivera M, et al. Effect of a commercially available low-dose capsaicin supplement on knee extensor contractile function. Int J Exerc Sci. 2020;13(2):312-322.
Moura e Silva VEL, de Souza Neto AV, Moreira SB, et al. Capsaicinoids and Capsinoids as an ergogenic aid: a systematic review and the potential mechanisms involved. Int J Sports Physiol Perform. 2021;16(4):464-473. doi:10.1123/ijspp.2020-0308
Opheim MN, Rankin JW. Effect of capsaicin supplementation on repeated sprinting performance. J Strength Cond Res. 2012;26(2):319-326. doi:10.1519/JSC.0b013e31821a413d
Al-Metwali B, Mulla H. Personalized dosing of medicines for children. J Pharm Pharmacol. 2017;69(5):514-524. doi:10.1111/jphp.12695
Karelis AD, Chamberland G, Aubertin-Leheudre M, Duval C, Ecological validity of a portable bioelectrical impedance analyzer for the assessment of body composition. Appl Physiol Nutr Metab. 2013;38(9):999-1004. doi:10.1139/apnm-2013-0027
Fonseca ICS, Silva LB, Carvalho JF, et al. Subsequent performance of two 1RM tests in the same session reduces 1RM and consequently the volume load of strength training session. J Exerc Physiol Online. 2020;23(5):65-75.
Robertson RJ, Goss FL, Rutkowski J, et al. Concurrent validation of the OMNI perceived exertion scale for resistance exercise. Med Sci Sports Exerc. 2003;35(2):333-341. doi:10.1249/01.MSS.0000048831.15016.2A
Esformes JI, Bampouras TM. Effect of back squat depth on lower-body postactivation potentiation. J Strength Cond Res. 2013;27(11):2997-3000. doi:10.1519/JSC.0b013e31828a1f93
O'Neill J, Brock C, Olesen AE, Andresen T, Nilsson M, Dickenson AH. Unraveling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol Rev. 2012;64(4):939-971. doi:10.1124/pr.112.006163
Drake D, Kennedy R, Wallace E. Familiarization, validity and smallest detectable difference of the isometric squat test in evaluating maximal strength. J Sports Sci. 2018;36(18):2087-2095. doi:10.1080/02640414.2018.1439872
Pérez-Castilla A, Jiménez-Reyes P, González-Badillo JJ. Reliability and concurrent validity of seven commercially available devices for the assessment of movement velocity at different intensities during the bench press. J Strength Cond Res. 2019;33(5):1258-1265. doi:10.1519/JSC.0000000000002015
Sanchez-Medina L, González-Badillo JJ. Velocity loss as an indicator of neuromuscular fatigue during resistance training. Med Sci Sports Exerc. 2011;43(9):1725-1734. doi:10.1249/MSS.0b013e318216eb99
Garnacho-Castaño MV, Domínguez R, Mate-Muñoz JL. Acute physiological and mechanical responses during resistance exercise at the lactate threshold intensity. J Strength Cond Res. 2015;29(10):2867-2873. doi:10.1519/JSC.0000000000000965
Rhea MR. Determining the magnitude of treatment effects in strength training research through the use of the effect size. J Strength Cond Res. 2004;18(4):918-920. doi:10.1519/14403.1
Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Elsevier; 1988.
Li S, Zheng J. The capsaicin binding affinity of wild-type and mutant TRPV1 ion channels. J Biol Chem. 2023;299(11):102968. doi:10.1016/j.jbc.2023.102968
Freitas MC, Moreira SB, Moura e Silva VEL, et al. Acute capsaicin supplementation improved resistance exercise performance performed after a high-intensity intermittent running in resistance-trained men. J Strength Cond Res. 2022;36(1):130-134. doi:10.1519/JSC.0000000000003587
Zhou G, Su Y, Fa S, et al. Diversity effect of capsaicin on different types of skeletal muscle. Mol Cell Biochem. 2018;443:11-23. doi:10.1007/s11010-017-3211-6
Chin ER. Intracellular Ca2+ signaling in skeletal muscle: decoding a complex message. Exerc Sport Sci Rev. 2010;38(2):76-85. doi:10.1097/JES.0b013e3181d496d5
Arkhipov AY, Shilnikov VV, Chistopol’skii IA, et al. Activation of TRPV1 channels inhibits the release of acetylcholine and improves muscle contractility in mice. Cell Mol Neurobiol. 2023;43(8):4157-4172. doi:10.1007/s10571-023-01364-w
Jiménez-Martínez P, Peinado AB, Garnacho-Castaño MV, et al. Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial. J Int Soc Sports Nutr. 2023;20(1):2204083. doi:10.1080/15502783.2023.2204083
Jiménez-Martínez P, Peinado AB, Garnacho-Castaño MV, et al. Effects of different phenylcapsaicin doses on neuromuscular activity and mechanical performance in trained male subjects: a randomized, triple-blinded, crossover, placebo-controlled trial. Front Physiol. 2023; 14:1149320. doi:10.3389/fphys.2023.1149320
Mannozzi J, Groebe B, Hellsten Y, Leicht AS, Green S. Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex. Am J Physiol Regul Integr Comp Physiol. 2021;321(3):R385-R395. doi:10.1152/ajpregu.00052.2021
Downloads
Posted
Categories
License
Copyright (c) 2025 Matheus Dias Mendes, Brena de Oliveira, Marcos Antonio Pereira dos Santos, Fernando Vitor Lima, Marcos Daniel Motta Drummond (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
