Powerpenia
Should it be considered a biomarker of healthy aging?
DOI:
https://doi.org/10.51224/SRXIV.358Keywords:
dynapenia, health, sedentarism, sarcopenia, neuromuscular function, quality of lifeAbstract
To identify biomarkers that precede the human function decline and independence during lifespan, two important concepts have been introduced in the last decades: sarcopenia and dynapenia. While the former is originally focused on skeletal muscle loss, the latter is on maximal strength loss. Although the dynapenia concept foresees the inclusion of skeletal muscle power, in practical terms, this has not been specifically addressed. For instance, only 2 out of 220 studies published between 2008 and 2023 have directly measured muscle power to classify individuals with dynapenia. As previous studies have shown a greater relevance of skeletal muscle power in healthy aging, we hereby propose the introduction of the term named “powerpenia” to specifically reflect the loss of skeletal muscle power along lifespan. Together with sarcopenia and dynapenia, we contend that powerpenia should be considered a biomarker of healthy aging.
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References
Katzmarzyk PT, Lee I-M. Sedentary behaviour and life expectancy in the USA: a cause-deleted life table analysis. BMJ Open [Internet]. 2012;2. Available from: http://dx.doi.org/10.1136/bmjopen-2012-000828
Reid KF, Fielding RA. Skeletal muscle power: a critical determinant of physical functioning in older adults. Exerc Sport Sci Rev. 2012;40:4–12.
Alcazar J, Rodriguez-Lopez C, Delecluse C, Thomis M, Van Roie E. Ten-year longitudinal changes in muscle power, force, and velocity in young, middle-aged, and older adults. J Cachexia Sarcopenia Muscle. 2023;14:1019–32.
Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr. 1997;127:990S – 991S.
Cruz-Jentoft AJ, Morley JE. Sarcopenia. John Wiley & Sons; 2021.
Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci. 2008;63:829–34.
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39:412–23.
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16–31.
Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet. 2019;393:2636–46.
Petermann-Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP, et al. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2022;13:86–99.
Bülow J, Ulijaszek SJ, Holm L. Rejuvenation of the term sarcopenia. J Appl Physiol. 2019;126:255–6.
Suetta C, Haddock B, Alcazar J, Noerst T, Hansen OM, Ludvig H, et al. The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 years [Internet]. Journal of Cachexia, Sarcopenia and Muscle. 2019. p. 1316–29. Available from: http://dx.doi.org/10.1002/jcsm.12477
Radaelli R, Trajano GS, Freitas SR, Izquierdo M, Cadore EL, Pinto RS. Power Training Prescription in Older Individuals: Is It Safe and Effective to Promote Neuromuscular Functional Improvements? Sports Med. 2023;53:569–76.
Wilkinson DJ, Piasecki M, Atherton PJ. The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Res Rev. 2018;47:123–32.
Sapega AA, Drillings G. The definition and assessment of muscular power. J Orthop Sports Phys Ther. 1983;5:7–9.
Knudson DV. Correcting the use of the term “power” in the strength and conditioning literature. J Strength Cond Res. 2009;23:1902–8.
Wiegmann S, Felsenberg D, Armbrecht G, Dietzel R. Longitudinal changes in muscle power compared to muscle strength and mass. J Musculoskelet Neuronal Interact. 2021;21:13–25.
Correia JP, Vaz JR, Domingos C, Freitas SR. From thinking fast to moving fast: motor control of fast limb movements in healthy individuals. Rev Neurosci. 2022;33:919–50.
Morley JE, Abbatecola AM, Argiles JM, Baracos V, Bauer J, Bhasin S, et al. Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc. 2011;12:403–9.
Michalak RE. Comment on: “Power Training Prescription in Older Individuals: Is it Safe and Effective to Promote Neuromuscular Functional Improvements?” Sports Med. 2023;53:2281–2.
Alcazar J, Aagaard P, Haddock B, Kamper RS, Hansen SK, Prescott E, et al. Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan. J Gerontol A Biol Sci Med Sci. 2020;75:1369–78.
Hester GM, Ha PL, Dalton BE, VanDusseldorp TA, Olmos AA, Stratton MT, et al. Rate of Force Development as a Predictor of Mobility in Community-dwelling Older Adults. J Geriatr Phys Ther. 2021;44:74–81.
Simpkins C, Yang F. Muscle power is more important than strength in preventing falls in community-dwelling older adults. J Biomech. 2022;134:111018.
Cousins JM, Petit MA, Paudel ML, Taylor BC, Hughes JM, Cauley JA, et al. Muscle power and physical activity are associated with bone strength in older men: The osteoporotic fractures in men study. Bone. 2010;47:205–11.
Luo J, Su L, Ndeke JM, Wang F, Hendryx M. Gait speed, handgrip strength, and cognitive impairment among older women - A multistate analysis. Exp Gerontol. 2022;169:111947.
Veronese N, Stubbs B, Trevisan C, Bolzetta F, De Rui M, Solmi M, et al. Poor Physical Performance Predicts Future Onset of Depression in Elderly People: Progetto Veneto Anziani Longitudinal Study [Internet]. Physical Therapy. 2017. p. 659–68. Available from: http://dx.doi.org/10.1093/ptj/pzx017
Balachandran AT, Steele J, Angielczyk D, Belio M, Schoenfeld BJ, Quiles N, et al. Comparison of Power Training vs Traditional Strength Training on Physical Function in Older Adults: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022;5:e2211623.
Byrne C, Faure C, Keene DJ, Lamb SE. Ageing, Muscle Power and Physical Function: A Systematic Review and Implications for Pragmatic Training Interventions. Sports Med. 2016;46:1311–32.
Lopez P, Rech A, Petropoulou M, Newton RU, Taaffe DR, Galvão DA, et al. Does high-velocity resistance exercise elicit greater physical function benefits than traditional resistance exercise in older adults? A systematic review and network meta-analysis of 79 trials. J Gerontol A Biol Sci Med Sci [Internet]. 2022; Available from: http://dx.doi.org/10.1093/gerona/glac230
Singh H, Kim D, Kim E, Bemben MG, Anderson M, Seo D-I, et al. Jump test performance and sarcopenia status in men and women, 55 to 75 years of age. J Geriatr Phys Ther. 2014;37:76–82.
Allen NE, Canning CG, Sherrington C, Fung VSC. Bradykinesia, muscle weakness and reduced muscle power in Parkinson’s disease. Mov Disord. 2009;24:1344–51.
Volpato S, Bianchi L, Lauretani F, Lauretani F, Bandinelli S, Guralnik JM, et al. Role of muscle mass and muscle quality in the association between diabetes and gait speed. Diabetes Care. 2012;35:1672–9.
Ramsey KA, Rojer AGM, D’Andrea L, Otten RHJ, Heymans MW, Trappenburg MC, et al. The association of objectively measured physical activity and sedentary behavior with skeletal muscle strength and muscle power in older adults: A systematic review and meta-analysis. Ageing Res Rev. 2021;67:101266.
Ramírez-Vélez R, Izquierdo M, García-Hermoso A, Ordoñez-Mora LT, Cano-Gutierrez C, Campo-Lucumí F, et al. Sit to stand muscle power reference values and their association with adverse events in Colombian older adults. Sci Rep. 2022;12:11820.
Nascimento CF do, Roman Lay AA, Duarte YAO, Chiavegatto Filho ADP. Functional mobility and 10-year all-cause and cause-specific mortality in older people from São Paulo, Brazil. Braz J Phys Ther. 2022;26:100431.
Rose DJ, Lucchese N, Wiersma LD. Development of a multidimensional balance scale for use with functionally independent older adults. Arch Phys Med Rehabil. 2006;87:1478–85.
Naruse M, Trappe S, Trappe TA. Human skeletal muscle-specific atrophy with aging: a comprehensive review. J Appl Physiol. 2023;134:900–14.
Vianna LC, Oliveira RB, Araújo CGS. Age-related decline in handgrip strength differs according to gender. J Strength Cond Res. 2007;21:1310–4.
Skelton DA, Greig CA, Davies JM, Young A. Strength, power and related functional ability of healthy people aged 65-89 years. Age Ageing. 1994;23:371–7.
Shu J, Jin W. Prioritizing non-communicable diseases in the post-pandemic era based on a comprehensive analysis of the GBD 2019 from 1990 to 2019. Sci Rep. 2023;13:13325.
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Copyright (c) 2023 Sandro Freitas, Carlos Cruz-Montecinos, Sébastien Ratel, Ronei S. Pinto (Author)
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