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Nutritional Supplements in the Clinical Management of Tendinopathy

A Scoping Review


  • Ian Burton NHS
  • Aisling McCormack



Nutrition, Tendinopathy, Tendon, Sports Nutrition, Supplement, Nutraceutical


Introduction: Tendinopathy has a high prevalence and incidence in the general population and among athletes, with a lack of consensus among medical practitioners on optimal management strategies. This scoping review aimed to map existing evidence on nutritional supplement interventions in the clinical management of tendinopathies.

Methods: This scoping review was reported in accordance with the PRISMA-ScR. Databases searched included MEDLINE, CINAHL, AMED, EMBase, SPORTDiscus, and the Cochrane library (Controlled trials, Systematic reviews). All primary study designs investigating nutritional supplement interventions in the clinical management of tendinopathies were considered for inclusion.

Results: 1527 articles were identified with 16 included in the review. Studies investigated a range of nutritional supplements in the clinical management of various tendinopathies, including several commercially available proprietary blends of several ingredients. TendoActive (Mucopolysaccharides, type-1 collagen & vitamin C) was used in two studies, TENDISULFUR (MSM, hydrolysed collagen, L-arginine, L-lysine, Vitamin C, Bromelain, Chondroitin, Glucosamine, Boswellia, & Myrrh) was used in three studies, Tenosan (Arginine-L-alpha ketoglutarate, hydrolysed collagen type-1, MSM, vitamin C, and bromelain, vinitrox) was used in two studies. Collagen peptides were used in 2 studies, with omega 3 fatty acids, combined fatty acids and antioxidants, turmeric rhizome combined with Boswellia, HMB, Vitamin C in isolation and combined with gelatin, and creatine investigated in one study each.

Conclusion: Despite a paucity of studies to date, findings from this review suggest that several nutritional compounds may be beneficial in the clinical management of tendinopathies, by exerting anti-inflammatory effects and improving tendon healing. Nutritional supplements may have potential as an adjunctive method to standard treatment methods such as exercise, where their pain relieving, anti-inflammatory, and structural tendon effects may augment the positive functional outcomes gained from progressive exercise rehabilitation.


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